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pentobarbital will reduce the level or influence of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital boosts effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor. Coadministration of ifosfamide with CYP2B6 inducers might raise metabolism of ifosfamide to its me